Danazol (Danocrine) and gestrinone are synthetic male hormones that lower estrogen levels, prevent menstruation, and shrink endometrial tissues.This state of pseudopregnancy means reduced pelvic pain and a temporary withering of endometrial implants. Continuously taking estrogen-progestin pills tricks the body into thinking it is pregnant. This explanation postulates that an unidentified substance found in the body forces cells from the lining of the body cavity to change into endometrial cells. According to this hypothesis, remnants of tissue left over from prenatal development of the woman's reproductive tract transforms into endometrial cells throughout the body. This theory suggests that the lymph system or blood vessels (vascular system) is the vehicle for the distribution of endometrial cells out of the uterus. However, many women with reversed menstrual flow do not develop endometriosis. Reversed menstrual flow occurs in 70-90% of women and is thought to be more common in women with endometriosis. There is considerable evidence to support this explanation. Originally proposed in the 1920s, this theory states that a reversal in the direction of menstrual flow sends discarded endometrial cells into the body cavity where they attach to internal organs and seed endometrial implants.
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